1) p210 bcr/abl protein
p210 bcr/abl蛋白
1.
Methods Human Ph + CML leukemia K562 cells, which express endogenous p210 bcr/abl protein, were cultured in RPMI 1640 and treated with berbamine as indicated time and dose.
方法培养表达内源性p210 bcr／abl蛋白的Ph+人慢性粒细胞白血病细胞系K562,用小檗胺按指定时间和剂量干预细胞。
2) P210 protein
P210融合蛋白
1.
The study was aimed to investigate the effects of emodin on proliferation inhibition and apoptosis induction in human chronic myeloid leukemia cell line K562 cells,and to explore the role of P210 protein and activation of caspase 3 in these processes.
本研究观察中药大黄素(emodin)对人慢性髓系白血病K562细胞株的增殖及凋亡影响,探讨P210融合蛋白和caspase-3激活在其中的作用。
3) Bcr-Abl protein
Bcr-Abl蛋白
1.
Methods The amounts of Bcr-Abl protein were tested by Western blot.
结果NB能降低HL-60/Bcr-Abl细胞中Bcr-Abl的蛋白水平,NB使Bcr-Abl与Hsp90和Hsp70的结合减少,促进蛋白酶体降解Bcr-Abl蛋白,ALLnL处理后NP-40insoluble部分Bcr-Abl蛋白水平提高。
2.
Aim To confirm the effects of Hsp90 inhibitor NB on STI571 resistant K562/G01 cells,and reveal the effect of combination of NB and STI571 on STI571 sensitive or resistant cells;to further clarify the relationship between growth inhibition and Bcr-Abl protein level and its kinase activity.
目的研究热休克蛋白90(Hsp90)抑制剂新生霉素(novobiocin,NB)对STI571耐药K562/G01细胞生长的抑制作用,并研究NB和STI571联合应用对STI571敏感和耐药细胞的作用,并进一步探讨该作用与Bcr-Abl蛋白水平和Bcr-Abl激酶水平的关系。
4) Bcr-Abl
Bcr-Abl蛋白
1.
Inhibition of Novobiocin on Proliferation of Bcr-Abl-positive Human Leukemia Cells Involves Disruption Chaperon Function of Hsp90;
Bcr-Abl蛋白是由bcr/abl融合基因编码的,具有比正常的p145c-abl激酶更强的酪氨酸激酶活性,是慢性粒细胞白血病(CML)对抗化疗药物诱导凋亡的。
5) p210~(bcr/abl) fusion protein
P21O~(bcr/abl)融合蛋白
6) BCR-ABL fusion protein
BCR-ABL融合蛋白
1.
To predict B cell epitope for the fusion region of BCR-ABL fusion protein(p210~(BCR-ABL))in chronic myeloid leukemia,based on BCR-ABL fusion protein sequence,the B cell epitope for BCR-ABL fusion region was predicted by methods of EMBOSS program,DNAstar software,hopp and woods hydrophility,Janin accessibility,polarity,flexibility and secondary structure.
以BCR-ABL融合蛋白氨基酸序列为基础,采用EMBOSS软件及DNAstar软件结合Hopp and Woods亲水性参数、Janin可及性参数、极性参数、柔韧性参数及二级结构方案对慢性粒细胞白血病BCR-ABL融合蛋白(p210~(BCR-ABL))融合区的B细胞表位进行预测。
补充资料：钋-210(polonium-210)
【钋-210】(polonium-210)俗称“镭F（RaF）”。质量数为210的钋的天然放射性核素。半衰期138.4天。发射`\alpha`辐射。可从阵氡管中提取。与轻元素铍均匀混合紧密压制可制成钋-铍中子源。用于油井测井及实验室研究，也可用作`\alpha`射线标准源。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条