Selective cytotoxicity of three adenosine analogues on carcinoma cells;

Studies on the inhibition of invasion of human ovarian carcinoma cells by adenosine analogues;

Adenosine analogues have the same bioactivities as adenosine,but are slowly deaminated by adenosine deam inase.

Synthesis of (4 R,5R)-4-(N -methyl-hydroxyamino)-5-( tert -butyldiphenylsiloxymethyl)-3,4-dihydro-2(5H)-furanone,key intermediate for a series of nucleoside analogs,was studied.

Six nucleoside analogs (nucleoside with two sugars) were determinde by HRFAB MS.

The recent progress of nucleoside analogues as anticancer agents is reviewed.

In this article,we reviewed current anti-HBV drugs,such as interferon,nucleoside analogue,immunomodulatory drugs and gene therapy in the aspects of pharmacologic action and clinical therapeutic effects.

The nucleoside analogue such as ara\|C and CNDAC exert their antitumor activities through incorporation into DNA strand, inhibiting DNA synthesis and causing the cell kill.

The efficacy of nucleosides plus artificial liver support system on treating chronic severe hepatitis;

5 mg and with lamivudine 100 mg were well tolerated,and compared to none-nucleoside analogues treated patients,had no significantly difference in survival rate(P＞0.