A useful synthetic route to dibenzylbutylester lignans was described using piperonal and vera-traldehyde as the starting materials.

Result: Seven lignans were isolated and identified as erythro-guaiacylglycerol-β-O-4′-sinapyl ether(1),1-(4′-hydroxy-3′-methoxyphenyl)-2-[4″-(3-hydroxypropyl)-2″,6″-dimethoxyphenoxy]propane-1,3-diol(2),isolariciresinol(3),burselignan(4),lyoniresinol(5),5-methoxy-isolariciresinol(6),cycloolivil(7).

Prediction of ~(13)C NMR chemical shifts of lignans of butane's derivatives;