Taking advantage of the steric effect of nitrogen atoms in 2-methylpiperazine, selective monobenzoylate on the nitrogen atoms were investigated by five synthetic routes.

The efficacy and safety of methyclothiazide tablets in treatment of patients with mild-to-moderate essential hypertension;

Study of pharmacokinetics and LC-MS/MS method of blood concentration of methyclothiazide;

Liquid chromatography/tandem mass spectrometry for the determination of Methyclothiazide in human plasma;