To study the effect of chemical and physical treatments on the protease resistance of scrapie 263K,PrP Sc from hamsters infected intracerebrally with scrapie strain 263K was treated with different concentrations of sodium hydroxide(NaOH), sodium hypochlorite(NaOCl) .

Second,damage can be attributed to an imbalance in the endogenous protease/antiprotease equilibrium,promoting tissue hydrolysis that leads to alveolar septal rupture by digestion of septal matrix proteins.

Role of protease-antiprotease imbalance in pulmonary contusion in rabbits;