Four human immortalized keratinocyte(HaCaT) clones with CCL20 gene knockdown(CloneⅡ-Ⅴ) and untransfected HaCaT cells(cloneⅠ) were served as experimental groups and control group,respectively.

Breeding,reproducing and identifying for aquaporin-3 gene knock-out mice;

Gene knock-out technology and its application in the research of c-Jun NH2-Terminal Kinase-2

Construction and characterization of a two-component signal transduction system ciaR gene knock-out mutant of Streptococcus suis serotype 2

Effect of p53 gene knockout on cell migration;

Analysis of focal cerebral blood flow,ATP content and protein sythesis of L1 gene knockout mice;

Establishment of a βB2 crystallin gene knockout mice model;

Immortalization of embryonic fibroblasts in heat shock transcription factor 1 knockout mouse;

Effect of Smad4 Knockout on Hearing and Vestibular Function of Mouse;

Experimental observations on the physiology of hearing and cochlea morphology in Smad5 knockout mice;

Effects of protein tyrosine phosphatase α knock out on Hippocampal CA1 synaptic plasticity;

Objective To study the role of Schwann cells apoptosis in the pathogenesis of experimental autoimmune neuritis(EAN) in TNF receptor Ⅰ knock out(TNFR Ⅰ-/-)mice.

7kb exon6 to exon7 DNA sequence which is separated by PCR as Short Arm(SA),were used to construct HPRT gene knock out vector.

To further study the biological function and expression of adiponection in vivo, adipoenctin gene knock-out and LacZ gene knock-in mouse model was constructed.